It has been used successfully for the following: to calm
fractious horses
; to provide relief from
abdominal pain
; and to facilitate bronchoscopy, bronchoalveolar lavage, nasogastric intubation, nonreproductive rectal palpations, suturing of skin lacerations, and castrations.
Is detomidine the same as medetomidine?
Medetomidine, dexmedetomidine, and detomidine are more specific for the alpha 2 receptor than xylazine. Dexmedetomidine has twice the potency of medetomidine. Therefore these drugs should not be used interchangeably without consulting the dose recommendations.
What is the drug detomidine Dormosedan used for?
What is
dormosedan gel
? Dormosedan Gel is an oromucosal sedative containing detomidine hydrochloride. It is prescribed by veterinarians to allow procedures to be done in an anxious horse Dormosedan Gel has not been shown to provide analgesia and should not be used for painful procedures.
Can detomidine be reversed?
Conclusions and potential relevance:
single bolus administration
of atipamezole or tolazoline produced partial reversal of
detomidine sedation
and may be useful for minimising detomidine sedation.
How long does Detomidine last in horses?
Detomidine in the gel form (Dormosedan Gel) for horses is administered orally to produce mucosal absorption. It is indicated for producing minor standing sedation to facilitate minor procedures (shoeing, clipping, trimming) or calming a fractious horse. Onset of action is 40 minutes, and duration is 90–180 minutes.
What class of drug is Detomidine?
Detomidine is an α2-adrenergic agonist that is used as a horse sedative. Normally, it is administered in the salt form, detomidine hydrochloride. This drug is prescribed by veterinarians and is marketed as Dormosedan.
Is medetomidine a controlled drug?
Other drugs Other Controlled Drugs commonly used in anaesthesia include ketamine and butorphanol; in some cases, used on their own or, in some cases, in combination with medetomidine or midazolam.
How long does Dormosedan stay in a horses system?
Remove gloves for disposal. For the best results, allow adequate time (a minimum of 40 minutes) between administration of DORMOSEDAN GEL and beginning the procedure. In general, horses show sedative effects lasting approximately 90-180 minutes.
What type of drug is Dormosedan?
Dormosedan ® , a non-narcotic sedative and analgesic , is a potent α 2 -adrenoreceptor agonist which produces sedation and superficial and visceral analgesia which is dose dependent in its depth and duration.
What are the side effects of Dormosedan?
Food and water should be withheld until the sedative effect of Dormosedan® has worn off. ADVERSE REACTIONS: Occasional reports of anaphylactic-like reactions have been received, including 1 or more of the following: urticaria, skin plaques, dyspnea, edema of the upper airways, trembling, recumbency, and death.
Which are common side effects of Detomidine in the equine patent?
Detomidine caused a decrease in heart rate at all doses and other observed side-effects included ataxia, heavy breathing, arrhythmia, sweating and frequent urination No adverse effects were observed.
How quickly does Dormosedan gel work?
It takes a good 1-2 hours to completely take effect so make sure you allow time for this – if you excite the horse in the meantime, it just won’t work! Dormosedan Gel contains the stronger Detomidine Hcl.
How long does atipamezole last?
The effects of atipamezole typically last two to three hours , which can be significantly shorter than the agents it is reversing; therefore, multiple doses may be indicated based on clinical signs that the animal is exhibiting (especially recurrence of significant cardiovascular signs).
Can you overdose on ANTISEDAN?
Over dosage Atipamezole was tolerated in healthy dogs receiving doses 10-fold the recommended dose and in dogs receiving repeated doses at 1-, 3-, and 5-fold doses, in the absence of an α2-antagonist. Signs of overdose were dose-related and consistent with those expected in non-sedated dogs having received a stimulant.
Can ANTISEDAN be given subcutaneous?
ANTISEDAN is administered intramuscularly (IM) for reversal of sedation and analgesia regardless of the route used for DEXDOMITOR or DOMITOR.
Can farriers sedate horses?
Several farriers indicated sedation helps keep all parties involved when working on a difficult horse , especially if the owner has to pay the vet to administer the drug. Other farriers pointed out that most horses that require sedation are normally in pain or lame.
Is dexamethasone a steroid?
Dexamethasone is a steroid (corticosteroid) medicine Steroids closely copy the effects of natural hormones produced in your adrenal glands. The adrenal glands sit above your kidneys. When prescribed in doses higher than your body’s usual levels, steroids like dexamethasone reduce inflammation.
What does banamine do for a horse?
Banamine is a nonsteroidal anti-inflammatory agent that relieves pain, swelling and fever in horses. Banamine comes in two forms: injectable and oral. Veterinarians routinely use the injectable form in the vein (IV). Horse owners may have oral and injectable banamine on hand to relieve pain.
Is stadol a morphine?
Stadol (butorphanol tartrate) is a narcotic pain reliever, similar to morphine used to treat moderate to severe pain. Stadol is also used as part of anesthesia for surgery, or during early labor (if childbirth is expected to be more than 4 hours away).
What is Atipamezole used for?
Atipamezole (Antisedan ® ) is an α-2 adrenergic antagonist labeled for use as a reversal agent for the sedative medetomidine It has been used successfully in the treatment of amitraz toxicosis to reverse CNS depression, bradycardia, GI stasis and hyperglycemia (Grossman, 1993; Gwaltney-Brant, 2004).
Can horses eat on Dormosedan gel?
DORMOSEDAN GEL produces sedation when administered under the tongue at 0.018 mg/lb (0.040 mg/kg). DORMOSEDAN GEL must be placed beneath the tongue of the horse and is not meant to be swallowed.
Is Dormosedan gel safe for horses?
DORMOSEDAN GEL ® (detomidine hydrochloride) is a safe and effective mild standing sedative for use prior to routine horse care procedures.
Can you give Dexdomitor sq?
Conclusions: Dexmedetomidine is relatively rapidly and efficiently absorbed after SC administration. Subcutaneous dexmedetomidine may be a feasible alternative in palliative sedation , and causes attenuated cardiovascular effects compared to IV administration.
How is ANTISEDAN given?
ANTISEDAN is administered intramuscularly (IM) for reversal of sedation and analgesia regardless of the route used for DEXDOMITOR or DOMITOR. The atipamezole dose for the reversal of IV DEXDOMITOR or DOMITOR is 3750 mcg/m2.
Can cats get ANTISEDAN?
Do not use DEXDOMITOR or DEXDOMITOR 0.1 in dogs or cats , and ANTISEDAN in dogs, with cardiovascular disease, respiratory disorders, liver or kidney diseases, or in conditions of shock, severe debilitation, or stress due to extreme heat, cold or fatigue.
What drug is used to put horses to sleep?
Lethal injection with a barbiturate, typically pentobarbital , is the method most commonly employed by veterinarians in the United States. The barbiturates used are DEA controlled substances so this method can only be carried out by a licensed veterinarian.
How do you naturally sedate a horse?
Two herbs commonly found in calming products are valerian root and chamomile , both reported to soothe edginess and function as a sleep aid, although valerian is the stronger of the two and is considered a banned substance by some equine associations.
How much tranquilizer should I give my horse?
Doses range from 100-200 mg iv (1-2cc of 100mg/ml) for most horses. Larger horses are more sensitive and young horses generally need more per pound of bodyweight. Allow horses to sedate fully before stimulating or the sedation may not take effect.
How long does horse Xylazine last?
The principal pharmacological activities develop within 10 to 15 minutes after intramuscular injection, and within 3 to 5 minutes following intravenous administration in horses. A sleeplike state, the depth of which is dose-dependent, is usually maintained for 1 to 2 hours , while analgesia lasts from 15 to 30 minutes.
Can dogs have Dormosedan?
Dormosedan is available from MWI Veterinary Supply Depending on the size of the dogs you treat, you can usually dose 5-6 dogs/syringe.
Does medetomidine cause muscle relaxation?
Alpha 2 -agonists such as xylazine and medetomidine are sedative-hypnotic agents that provide sedation, muscle relaxation , and analgesia.
How do vets dispose of Tramadol?
Residual or waste drugs The VMD advise that CDs should be rendered irretrievable before disposal , e.g. by using a denaturing kit. Alternatively, an injectable solution may be placed into sawdust or cat litter and tablets may be crushed and mixed with soapy water.
What is the difference between medetomidine and dexmedetomidine?
Medetomidine is faster acting and more effective than dexmedetomidine following IM administration in dogs. Medetomidine may induce less vasoconstriction at injection site, faster uptake and more rapid onset of action.
How much Dormosedan do you give a horse?
“I typically give 1.2 mls or 12 mgs of Dormosedan to the average 1,000 – 1,200 pound horse for the initial dose,” he said.
How do you give a horse Dormosedan?
Dosage & Administration Dormosedan Gel produces sedation when administered sublingually at 0.040 mg/kg body weight (0.018 mg/lb body weight). Dormosedan Gel must be placed beneath the tongue of the horse and is not meant to be swallowed The dosing syringe delivers the product in 0.25 mL increments.
When can horse eat after sedation?
Your horse should not eat hay or grain for at least 1-2 hours after a sedation and dental procedure. Once they are fully awake, most horses never miss a meal.
Sources
https://www.zoetisus.com/products/horses/dormosedan_gel/product_information.aspx
https://www.fda.gov/animal-veterinary/cvm-updates/fda-approves-first-generic-detomidine-hydrochloride-injectable-solution-horses
https://pubmed.ncbi.nlm.nih.gov/16706278/
https://www.drugs.com/pro/dormosedan.html